Brain-Derived Neurotrophic Factor, Copper, Zinc and High Density Lipoprotein (HDL) in Patients with Dementia
Petr Melnikov
School of Medicine, Federal University of Mato Grosso do Sul, Brazil
Kleber F. Meneghel Vargas
School of Medicine, Federal University of Mato Grosso do Sul, Brazil
Ana R. Coimbra
School of Medicine, Federal University of Mato Grosso do Sul, Brazil
Lourdes Zélia Zanoni *
School of Medicine, Federal University of Mato Grosso do Sul, Brazil
Valter A. Nascimento
School of Medicine, Federal University of Mato Grosso do Sul, Brazil
*Author to whom correspondence should be addressed.
Abstract
The levels of BDNF, copper, zinc and common blood tests of two different groups of patients were considered: those with dementia syndrome and healthy older people. It would be premature to conclude that these indicators, with the exception of high density lipoprotein (HDL), are directly associated with clinical manifestations of this disorder. The HDL levels were significantly lower in dementia patients, compared to healthy control group, so it is possible to suggest that HDL can perform a protective function.
Keywords: BDNF, dementia, HDL, MMSE, trace elements