Neurodynamic Influence of Hydrocortisone on Rhinencephalic and Telencephalic Brain Areas

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Ilochi Ogadinma
Daniel Yaro Onoja
Chuemere Arthur Nwafor


The neurodynamic effect of graded hydrocortisone treatment on rhinencephalic and telencephalic brain regions was studied in an experimental animal design that sampled isolated hippocampal, basal nucleic and frontal cortical brain regions of male wistar rats. Four test groups, ii to v were administered 2.5 mg, 5 mg, 7.5 mg and 10 mg respectively. The study period lasted for 6 weeks. Results were statistically analyzed and considered significantly different at a confidence interval of 95%. There was a progressive decline in olfactory response as dose of hydrocortisone treatment was increased. There was a significant dose-dependent decrease in assayed frontal cortical acetylcholine and hippocampal glutamate in brain tissue homogenates. Similar change was observed in brain tissue calcium, magnesium and sodium. For the behavioral, histological and biochemical tests conducted in this study, 6 weeks hydrocortisone treatment showed adverse manifestations from 5 mg, which was more obvious from 7.5 mg. The outcome of this study revealed a possible dose-dependent adverse effect of hydrocortisone on specific brain regions responsible for learning, memory, olfaction and psychosocial behavior.

Hydrocortisone, neurotransmitters, homogenates, behavior, histology.

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How to Cite
Ogadinma, I., Onoja, D. Y., & Nwafor, C. A. (2019). Neurodynamic Influence of Hydrocortisone on Rhinencephalic and Telencephalic Brain Areas. International Neuropsychiatric Disease Journal, 13(2), 1-7.
Original Research Article


Faresjo A, Theodorsson E, Chatziarzeni M, Sapouna V, Claesson H, Koppner J, Faresjo T. Higher perceived stress but lower cortisol levels found among young greek adults living in a stressful social environment in comparison with Swedish young adults; 2013.
Available: info:doi/10.1371/journal.pone.0073828

Kingkade T. Millennials are more stressed out than older generations: Stress in america survey; 2013.

Thirthalli J, Naveen GH, Rao MG, Varambally S, Christopher R, Gangadhar BN. Cortisol and antidepressant effects of yoga. Indian Journal of Psychiatry; 2013.
DOI: 10.4103/0019-5545.116315

McGonigal K. (Performer) Ted: How to make stress your friend [Theater]; 2013.
Available: mcgonigal_how_to_make_stress_your_friend.html

Liu D, Ahmet A, Ward L, Krishnamoorthy P, Mandelcorn ED, Leigh R, et al. A practical guide to the monitoring and management of the complications of systemic corticosteroid therapy. Allergy Asthma Clin Immunol. 2013;9(1):30.

Vinkers CH, Zorn JV, Cornelisse S, Koot S, Houtepen LC, Olivier B, Verster JC, Kahn RS, Boks MPM, Kalenscher T, Joëls M. Time-dependent changes in altruistic punishment following stress? Psychoneuroendocrinology. 2013;38(9): 1467–1475. Available:
(Retrieved 08.02.17)

Ogadinma Ilochi, Arthur Nwafor Chuemere. Neuroprotective potential of avocado peel correlates with antioxidant status in starvation and refeeding in wistar rats. World Wide Journal of Multidisciplinary Research and Development WWJMRD. 2019;5(1):70-74.

Ilochi ON, Kolawole TA, Oluwatayo BO, Chuemere AN. Starvation-induced changes in memory sensitization, habituation and psychosomatic responses. International Journal of Tropical Disease and Health. 2019;35(3):1-7.
Article no. IJTDH.48268. ISSN:2278-1005,NLM ID: 101632866

Margittai Z, Strombach T, Van Wingerden M, Joëls M, Schwabe L, Kalenscher T. A friend in need: Time-dependent effects of stress on social discounting in men. Horm. Behav. 2015;73:75–82.

Kandasamy N, Hardy B, Page L, Schaffner M, Graggaber J, Powlson AS, Fletcher PC, Gurnell M, Coates J. Cortisol shifts financial risk preferences? Proc.Natl. Acad. Sci. USA. 2014;111(9):3608–3613.
(retrieved 06.01.16)

Carvalho LS, Meier S, Wang SW. Poverty and economic decision-making: Evidence from changes in financial resources at payday? Am. Econ. Rev. 2016;106(2): 260–284.
(Retrieved 28.12.16)

Kolawole TA, Ilochi ON, Oluwatayo BO, Chuemere AN, Dapper DV. Tissue protein carbonylation in aging: A Strategic Analysis Of Age-Related Protein Modification. Journal of Advances in Medical and Pharmaceutical Sciences. 2019;20(3):1-5.
DOI: 10.9734/jamps/2019/v20i330111

Ilochi Ogadinma, Arthur Nwafor Chuemere, Ekwem Ikechukwu, Bassey Samuel. Neuroprotective and antitoxic potential of hydromethanolic extract of Allium cepa in experimental rats. European Journal of Pharmaceutical and Medical Research. Ejpmr. 2018;5(9):138-143.

Ilochi ON, Chuemere AN, Dapper DV, Saronee F, Ekwem I. Sleep duration in children and its influence on glucose homeostasis, ingestive behavior and primary examination performance. Archives of Current Research International. 2019;18(4):1-5.