International Neuropsychiatric Disease Journal

Anorexia nervosa is a serious eating disorder characterized by extreme food restriction, intense fear of gaining weight, and a distorted body image. This literature review synthesizes key research on the psychological, neurobiological, and genetic factors associated with anorexia nervosa. The disorder predominantly affects adolescent girls and young women and can have severe medical and psychological consequences. Research shows that psychological factors like perfectionism, body dissatisfaction, and low self-esteem contribute to the development and maintenance of anorexia. Neuroimaging studies reveal differences in brain regions related to reward processing and cognitive control in individuals with anorexia compared to healthy controls. These neural patterns may underlie the rigid, ritualistic eating behaviors and difficulties in changing thought patterns associated with the disorder. There is also evidence for a genetic component, with studies identifying associations between anorexia and variations in genes related to serotonin regulation, anxiety, obsessive-compulsive behaviors, and other psychiatric disorders. Integrating psychological, neurobiological, and genetic research provides greater insight into the multifaceted origins of anorexia nervosa. Understanding the complex factors that lead to and perpetuate the disorder can inform more effective, evidence-based treatments. Family-based therapy and cognitive-behavioral approaches focused on normalizing eating, addressing thought distortions, and building coping skills show promise. With comprehensive treatment, recovery from anorexia is possible, but early intervention is critical.