Gastrodia elata as a Neuroprotective Agent: A Mini-review of its Bioactive Compounds and Mechanisms of Action
UDI, OA *
Department of Human Anatomy, Faculty of Basic Medical Science, Federal University Otuoke, Bayelsa State, Nigeria.
OMURUKA, TC
Department of Human Anatomy, Faculty of Basic Medical Science, Federal University Otuoke, Bayelsa State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Gastrodia elata commonly called Tianmab is a traditional medicinal herb widely used in East Asia for its purported neuroprotective effects. This mini-review summarizes the current understanding of the bioactive compounds within G. elata and their potential mechanisms of action related to neuroprotection. Evidence suggests that compounds like gastrodin, gastrodial, and parishin exhibit antioxidant, anti-inflammatory, and anti-apoptotic properties, contributing to the protection of neuronal cells against various stressors. Further research is needed to fully elucidate the specific pathways involved and to translate these findings into clinically relevant applications for neurodegenerative diseases and other neurological disorders.
Keywords: Gastrodia elata, neuroprotection, gastrodin, anti-inflammatory, anti-apoptotic, neurodegenerative diseases