Assessment of Improvement in Feeding Behavior and Co Morbid Psychiatric Disorders in Morphine Addiction Period in Socialized Male Rats
Hamidreza Famitafreshi
Department of Physiology, Tehran University of Medical Science, International Campus, Tehran, Iran
Morteza Karimian *
Department of Physiology, Tehran University of Medical Science, Tehran, Iran
Fatemeh Attari
Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
*Author to whom correspondence should be addressed.
Abstract
Introduction: In previous studies, other function of adult hippocampal neurogenesis besides memory and learning has not been studied. The aim of this study is to discover other function of hippocampal neurogenesis, especially in addiction period.
Materials and Methods: In this experiment 48 male Sprague-Dawley were randomly divided in four groups: 1) socialized 2) isolated 3) addicted socialized rats 4) addicted isolated rats. At the end of experiments short term memory, feeding behavior, blood glucose, zinc, anxiety level and neurogenesis were assessed.
Results: Short term memory was impaired in addicted isolated rats compared to addicted socialized rats. Food consumption increased in addicted social rats compared to addicted isolated rats. Level of blood glucose increased in addicted socialized rats compared to addicted isolated rats. Anxiety level increased in addicted isolated rats compared to addicted socialized rats. Neurogenesis decreased in addicted isolated rats compared to addicted socialized rats. Zinc was elevated in addicted isolated rats compared to addicted socialized rats.
Conclusion: Feeding behavior can be regulated by adult hippocampal neurogenesis in addiction period, and socialization improves it. Also along with these positive effects co morbid psychiatric disorder such as an anxiety improves in addiction period.
Keywords: Neurogenesis, memory, Y-maze, anxiety, addicted, zinc and glucose